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Studies

RESEARCHES

on the benefits of red clover on the relief of menopausal symptoms
Numerous studies about red clover support the theory that phytoestrogens found in red clover may help relieve problems related to hot flushes, which are a frequently experienced in menopause1,2. Lately, red clover3 in particular has been one of the most studied plants in relation to menopause and its symptoms. Research results have shown that isoflavones, in addition to reducing the number of daily hot flushes, also treat vaginal dryness4.

Menopause does not only bring problems related to hot flushes, insomnia and mood swings, but also problems with general wellbeing. Vitamins B, D, C and zinc have been proven as beneficial5 in keeping good health and general wellbeing in women in their menopause, due to the beneficial impact on the health of bones, heart and cardiovascular system, cognitive skills and vasomotor symptoms. Impact of red clover was examined also in relation to bone strength, because osteoporosis is one of the most frequent diseases after menopause. Isoflavones6 found in red clover have a positive effect on concentration of lipids in plasma and bone density.

RESEARCHES

on the impact of red clover on hair, nails and skin
One of the main causes of poorer and self-conscious state of mind of women in menopause is the drop of oestrogen and collagen that changes skin, hair and nails. Hair becomes thinner, starts falling out and turns grey. Skin becomes less elastic, drier, thinner, and so most women think they’ve aged quickly, with wrinkles becoming more pronounced and deeper.

Researches have shown that an adult woman who used red clover extract for 90 days on average had visibly improved health of the scalp, skin and less hair fall-out7. It has been shown that consuming red clover also helps relieve other symptoms related to the drop in oestrogen during menopause, including low libido, mood, sleep and tiredness. In addition to the safe quantity of the red clover extract, Femisol also contains vitamin D and zinc, which have proven as beneficial in keeping hair, bones, skin and nails healthy.

RESEARCHES

on maca and alleviation of menopausal symptoms
Maca root functions as a natural antioxidant, which increase antioxidant level in the body. And antioxidants are important because they help neutralize harmful free radicals, prevent chronic diseases and prevent cell damage8.

Clinical researches have shown that maca has a positive impact on energy and endurance. Keeping positive energy level may also help in mood boosting, and some early studies even suggest that maca may reduce symptoms of depression9. Feeling unwell, irritability and anxiety are actually very frequent during menopause.

Maca is also beneficial for woman’s sexual health10, it is well tolerated in the body, and may improve libido and sexual function. A study from 2008 showed that maca is beneficial for women in menopause who have psychological problems and lack sexual desire11. Due to the regulation and control of the female sexual hormone (oestrogen), it may also alleviate symptoms of menopause12, such as night sweating and hot flushes, and even increase bone density.

RESEARCHES

on the alleviation of menopausal symptoms and ginseng
Thanks to the abundance of phytoestrogens that help women relieve menopausal symptoms in a natural way, Panax ginseng has been used for treating female health issues for centuries. Further, it has a positive effect on low blood sugar13 levels, improves sexual function14 and improves mood15. Analysis of study results16 has shown that ginseng contributes to brelieving postmenopausal symptoms as well as biomarkers that contribute to the increased risk of cardiovascular diseases.

Clinical symptoms, such as vhot flushes, night sweating, mood swings, irritability, anxiety, depressive symptoms, vaginal dryness, low libido, increased body weight, insomnia and hair thinning usually accompany menopause. Studies also show that ginseng may help reduce the severity and incidence of these symptoms17. The overview of clinical studies has shown that ginseng also efficiently increases sexual arousal in women in menopause, improves mood and reduces symptoms of depression.

RESEARCH

on the safety of red clover and impact on menopause
Numerous researches have shown that red clover isoflavones are safe for consumption and are well tolerated also in women with a family history of breast cancer. Scientists have assessed the safety of the standardized dietary supplement red clover isoflavone 40% in women with a family history of breast cancer. The three-year study supports more and more proofs that treatment with red clover isoflavones is safe18 and well tolerated by healthy women. Supplements that contain red clover isoflavones did not have an adverse effect on breast density, skeletal strength and cardiovascular status. In post-menopausal women, the endometrial status of the uterus was not affected.

Femisol is a dietary supplement, which, in addition to a dose of red clover isoflavones, also contains a combination of vitamins that contribute to healthy bones, nails and hair. This way it contributes to general wellbeing, appearance and health of menopausal women.

SOURCES

  • 1 Pitkin J1.; Red clover isoflavones in practice: a clinician's view.; J Br Menopause Soc. 2004 Mar;10 Suppl 1:7-12.
  • 2 Ghazanfarpour M, Sadeghi R, Latifnejad Roudsari R, Mirzaii Najmabadi K, Mousavi Bazaz M, Abdolahian S, Khadivzadeh T., Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis., Avicenna J Phytomed. 2015 Nov-Dec;5(6):498-511.
  • 3 Kargozar R, Azizi H, Salari R; A review of effective herbal medicines in controlling menopausal symptoms, Electron Physician. 2017 Nov 25;9(11):5826-5833. doi: 10.19082/5826.
  • 4 Oscar H. Franco, MD, PhD1; Rajiv Chowdhury, MD, PhD2; Jenna Troup, MSc1; Trudy Voortman, PhD1,3; Setor Kunutsor, MD, PhD2; Maryam Kavousi, MD, PhD1; Clare Oliver-Williams, PhD2; Taulant Muka, MD, PhD1,3; Use of Plant-Based Therapies and Menopausal Symptoms A Systematic Review and Meta-analysis, JAMA. 2016;315(23):2554-2563. doi:10.1001/jama.2016.8012
  • 5 Dennehy C, Tsourounis C.; A review of select vitamins and minerals used by postmenopausal women, Maturitas. 2010 Aug;66(4):370-80. doi: 10.1016/j.maturitas.2010.06.003. Epub 2010 Jun 26
  • 6 Stacie E. Geller, Laura Studee, MPH; Soy and Red Clover for Midlife and Aging; Climacteric. 2006 Aug; 9(4): 245–263.
  • 7 Markus Lipovac, Peter Chedraui, Christine Gruenhut, Anca Gocan, Christine Kurz, Benedikt Neuber, and Martin Imhof: Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women, Obstet Gynecol Int. 2011; 2011: 949302.
  • 8 Zha S, Zhao Q, Chen J, Wang L, Zhang G, Zhang H, Zhao B; Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii), Carbohydr Polym. 2014 Oct 13;111:584-7. doi: 10.1016/j.carbpol.2014.05.017. Epub 2014 May 21
  • 9 Stojanovska L1, Law C, Lai B, Chung T, Nelson K, Day S, Apostolopoulos V, Haines C.; Stojanovska L1, Law C, Lai B, Chung T, Nelson K, Day S, Apostolopoulos V, Haines C., Climacteric. 2015 Feb;18(1):69-78. doi: 10.3109/13697137.2014.929649. Epub 2014 Aug 7.
  • 10 Dording CM1, Fisher L, Papakostas G, Farabaugh A, Sonawalla S, Fava M, Mischoulon D.; A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction, CNS Neurosci Ther. 2008 Fall;14(3):182-91. doi: 10.1111/j.1755-5949.2008.00052.x.
  • 11 Brooks NA1, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L., Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content., Menopause. 2008 Nov-Dec;15(6):1157-62. doi: 10.1097/gme.0b013e3181732953
  • 12 H. O. Meissner, A. Mscisz, H. Reich-Bilinska, P. Mrozikiewicz, T. Bobkiewicz-Kozlowska, B. Kedzia, A. Lowicka, and I. Barchia; Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient study, Int J Biomed Sci. 2006 Dec; 2(4): 375–394. PMCID: PMC3614644
  • 13 Reay JL, Kennedy DO, Scholey AB; Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks., J Psychopharmacol. 2006 Nov;20(6):771-81. Epub 2006 Jan 9.
  • 14 Dai-Ja Jang, Myeong Soo Lee, Byung-Cheul Shin, Young-Cheoul Lee and Edzard Ernst; Red ginseng for treating erectile dysfunction: a systematic review, Br J Clin Pharmacol. 2008 Oct; 66(4): 444–450.
  • 15 Rai D1, Bhatia G, Sen T, Palit G.; Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study; J Pharmacol Sci. 2003 Dec;93(4):458-64.
  • 16 Kim SY1, Seo SK, Choi YM, Jeon YE, Lim KJ, Cho S, Choi YS, Lee BS., Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial; Menopause. 2012 Apr;19(4):461-6. doi: 10.1097/gme.0b013e3182325e4b
  • 17 Myung-Sunny Kim, Hyun-Ja Lim, Hye Jeong Yang, Myeong Soo Lee, Byung-Cheul Shin and Edzard Ernst; Ginseng for managing menopause symptoms: a systematic review of randomized clinical trials, J Ginseng Res. 2013 Mar; 37(1): 30–36. doi: 10.5142/jgr.2013.37.30
  • 18 Powles TJ, Howell A, Evans DG, McCloskey EV, Ashley S, Greenhalgh R, Affen J, Flook LA, Tidy A.: Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer., Menopause Int. 2008 Mar;14(1):6-12. doi: 10.1258/mi.2007.007033.
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